6/23/2006

Field page: Structural Biology

Description

The chemical behaviour of proteins is very strongly determined by their physical structure. For example, there are many enzymes that cease to function if their shape is distorted (Wikipedia has a rather nice diagram of this). As such, it's vitally important that we be able to figure out what shape proteins are.

Unfortunately, this turns out to be horrendously tricky. Proteins fold up in a fashion which is (usually) effectively deterministic, but which is so complicated that it takes the fastest computers and massive amounts of research to figure out what the damn things are going to look like. This research is collectively known as Structural Biology

Problem Solved

Given a protein sequence, how will it fold?

Books/Resources

"Introduction to Protein Science" - Arthur M. Lesk. Actually, this covers most CB fields, but it's the Structural Biology part I'm interested in. Barely started reading.

Posts

Ooh, pretty pictures

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